113學年材料所-第八週 專題研討課程 演講公告 (113年10月31日)
2024.10.29
題目: 功能化奈米材料從表面化學修飾到膜封裝的演變
演講者: 李偉鵬 教授
現職: 高雄醫學大學 醫藥暨應用化學系 副教授
時間: 113年10月31日(四) 下午15:10~17:00
地點: 成功大學成功校區三系館 鋼構區(3F)共同教室A1302演講廳
演講摘要:
A simple case demonstrates amino acids-modified Au@Cu2O nanoparticle to act as a catalysis-mediated biosensor, enabling the detection of the trace keto acids. Even though the mature surface chemical modification endows the various additional functions of specific nanomaterials, the inevitable risk of these nanomaterials injected into the body is to cause a robust immune response and potential toxicity. Advanced nanomaterials regarding extracellular vesicles (EVs) and membrane-camouflaged nanoparticles showing significant advantages and potential in various biomedical applications lead a bright direction. However, the poor yield of natural EVs has greatly restricted related developments. A practical approach, termed liposome fusion-induced membrane exchange (LIME), was established by feeding a high amount of DOPC/DOPE-made liposome to the exoelectrogenic bacteria (Shewanella oneidensis MR-1), thereby producing the biomimetic EVs with abundant electroactive c-type cytochromes (c-Cyts) in milligram quantities. These electroactive EVs were applied to coat the photocatalytic TiO2 nanoparticle (NP) that showed a significant enhancement of superoxide anions production under low dose X-ray activation, leading to enhanced tumor catalytic treatment. Moreover, a modified LIME was developed to generate the EVs from ACE2-expressing HeLa cells, followed by the preparation of ACE2-expressing membrane-camouflaged copper nanoparticles for decoying and killing SARS-CoV-2, which shows a feasible solution to overcome the COVID-19 pandemic and other infectious disease epidemics. The speech will also present more cases and future development of LIME and biomembrane-camouflaged nanomaterials.
歡迎各位撥冗參加!!
演講者: 李偉鵬 教授
現職: 高雄醫學大學 醫藥暨應用化學系 副教授
時間: 113年10月31日(四) 下午15:10~17:00
地點: 成功大學成功校區三系館 鋼構區(3F)共同教室A1302演講廳
演講摘要:
A simple case demonstrates amino acids-modified Au@Cu2O nanoparticle to act as a catalysis-mediated biosensor, enabling the detection of the trace keto acids. Even though the mature surface chemical modification endows the various additional functions of specific nanomaterials, the inevitable risk of these nanomaterials injected into the body is to cause a robust immune response and potential toxicity. Advanced nanomaterials regarding extracellular vesicles (EVs) and membrane-camouflaged nanoparticles showing significant advantages and potential in various biomedical applications lead a bright direction. However, the poor yield of natural EVs has greatly restricted related developments. A practical approach, termed liposome fusion-induced membrane exchange (LIME), was established by feeding a high amount of DOPC/DOPE-made liposome to the exoelectrogenic bacteria (Shewanella oneidensis MR-1), thereby producing the biomimetic EVs with abundant electroactive c-type cytochromes (c-Cyts) in milligram quantities. These electroactive EVs were applied to coat the photocatalytic TiO2 nanoparticle (NP) that showed a significant enhancement of superoxide anions production under low dose X-ray activation, leading to enhanced tumor catalytic treatment. Moreover, a modified LIME was developed to generate the EVs from ACE2-expressing HeLa cells, followed by the preparation of ACE2-expressing membrane-camouflaged copper nanoparticles for decoying and killing SARS-CoV-2, which shows a feasible solution to overcome the COVID-19 pandemic and other infectious disease epidemics. The speech will also present more cases and future development of LIME and biomembrane-camouflaged nanomaterials.
歡迎各位撥冗參加!!