114學年材料系-第十六週 專題研討課程 演講公告 (114年12月22日)
2025.12.19
114學年上學期 第十四週 專題研討課程 演講公告 (114年12月22日)
題目：刺激反應型高分子–奈米粒子複合材料之設計：精準癌症治療的新策略
講者：清大材料龔佩雲
時間：12/22 (一) 15:20~17:10
地點: 成功大學成功校區 三系館 A1307
內容摘要:
Boron Neutron Capture Therapy (BNCT) offers a unique approach to cancer treatment by enabling selective destruction of tumor cells at the cellular scale via high linear energy transfer (LET) particles generated from boron-10 neutron capture reactions. However, clinical progress has been constrained by limitations in boron drug design—namely, poor tumor selectivity, inadequate boron delivery, and suboptimal retention in solid tumors. This seminar introduces a nanomaterials-driven strategy to overcome these barriers through the rational design of stimuli-responsive polymer–nanoparticle hybrids.
We present a series of boron carbon oxynitride (BCNO)–based nanotherapeutics engineered for enhanced systemic delivery, tumor targeting, and controlled disassembly within the tumor microenvironment. Beginning with PEGylated BCNO nanoparticles to improve colloidal stability and passive accumulation, we advanced to folic acidfunctionalized constructs to exploit receptor-mediated uptake in triple-negative breast cancer (TNBC).
Our most recent platform, DHGC@BCNO, leverages electrostatic coassembly with PEG-g-PEI copolymers to form charge-tunable, pH-responsive nanoassemblies.
These hybrid systems remain stable during circulation but disassemble into highly cationic, sub-20 nm fragments under mildly acidic conditions, facilitating deep tumor penetration and cellular uptake.
In vivo, DHGC@BCNO achieved an 18-fold increase in tumor boron accumulation and significantly improved tumor-to-blood ratios over clinical benchmarks. When combined with α-PD-L1 immunotherapy, this platform induced complete inhibition of metastatic lung lesions—demonstrating, for the first time, an abscopal effect in BNCT.
This work highlights the transformative potential of hybrid materials design in creating precision nanomedicines.
歡迎各位撥冗參加!
題目：刺激反應型高分子–奈米粒子複合材料之設計：精準癌症治療的新策略
講者：清大材料龔佩雲
時間：12/22 (一) 15:20~17:10
地點: 成功大學成功校區 三系館 A1307
內容摘要:
Boron Neutron Capture Therapy (BNCT) offers a unique approach to cancer treatment by enabling selective destruction of tumor cells at the cellular scale via high linear energy transfer (LET) particles generated from boron-10 neutron capture reactions. However, clinical progress has been constrained by limitations in boron drug design—namely, poor tumor selectivity, inadequate boron delivery, and suboptimal retention in solid tumors. This seminar introduces a nanomaterials-driven strategy to overcome these barriers through the rational design of stimuli-responsive polymer–nanoparticle hybrids.
We present a series of boron carbon oxynitride (BCNO)–based nanotherapeutics engineered for enhanced systemic delivery, tumor targeting, and controlled disassembly within the tumor microenvironment. Beginning with PEGylated BCNO nanoparticles to improve colloidal stability and passive accumulation, we advanced to folic acidfunctionalized constructs to exploit receptor-mediated uptake in triple-negative breast cancer (TNBC).
Our most recent platform, DHGC@BCNO, leverages electrostatic coassembly with PEG-g-PEI copolymers to form charge-tunable, pH-responsive nanoassemblies.
These hybrid systems remain stable during circulation but disassemble into highly cationic, sub-20 nm fragments under mildly acidic conditions, facilitating deep tumor penetration and cellular uptake.
In vivo, DHGC@BCNO achieved an 18-fold increase in tumor boron accumulation and significantly improved tumor-to-blood ratios over clinical benchmarks. When combined with α-PD-L1 immunotherapy, this platform induced complete inhibition of metastatic lung lesions—demonstrating, for the first time, an abscopal effect in BNCT.
This work highlights the transformative potential of hybrid materials design in creating precision nanomedicines.
歡迎各位撥冗參加!